The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …

Background Sinonasal neoplasms, whether benign and malignant, pose a significant
challenge to clinicians and represent a model area for multidisciplinary collaboration in …

Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Simple Summary Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are essential
metabolic enzymes involved in the tricarboxylic acid (TCA) cycle. Several mutations in IDH …

Background Differentiating intrahepatic cholangiocarcinomas (iCCA) from hepatic
metastases of pancreatic ductal adenocarcinoma (PAAD) is challenging. Both tumours have …

Although the definitions of sinonasal neuroendocrine and neuroectodermal neoplasms did
not change substantially in the 5th edition WHO Classification of Head and Neck Tumours …

Precision in the diagnosis of diverse central nervous system (CNS) tumor types is crucial for
optimal treatment. DNA methylation profiles, which capture the methylation status of …

Tumor development is frequently accompanied by abnormal expression of multiple genomic
genes, which can be broadly viewed as decreased expression of tumor suppressor genes …

DNA methylation analysis based on supervised machine learning algorithms with static
reference data, allowing diagnostic tumour typing with unprecedented precision, has quickly …

Robustness has become an important consideration in deep learning. With the help of
explainable AI, mismatches between an explained model's decision strategy and the user's …