The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Sepsis is a life-threatening condition and a significant cause of preventable morbidity and
mortality globally. Among the leading causative agents of sepsis are bacterial pathogens …

SARS‐CoV‐2 infection causes an abrupt response by the host immune system, which is
largely responsible for the outcome of COVID‐19. We investigated whether the specific …

Candida albicans and Staphylococcus aureus account for most invasive fungal and
bacterial bloodstream infections (BSIs), respectively. However, the initial point of invasion …

Sepsis is a life-threatening condition driven by the dysregulation of the host immune
response to an infection. The complex and interacting mechanisms underlying sepsis …

Klebsiella pneumoniae is an opportunistic gram-negative pathogen causing serious
infections, including sepsis. In plasma, activation of the complement cascades is important …

补体C3对儿童脓毒症患者预后的预测价值- PMC Back to Top Skip to main content NIH NLM
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Objectives To investigate changes in complement component 3 (C3) levels in children with
sepsis and its correlation with the severity of sepsis and to explore the significance of C3 in …

Introduction 11 example, inflammation can affect activity of hepatic drug-metabolizing
enzymes [15][16] or kidney function [17], altering the rate of drug clearance. Quantitative …

Sepsis is currently defined as a life-threatening organ dysfunction that is caused by a
dysregulated host response to infection, affecting over 25 million people every year. In …