Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including
the unfolded protein response (UPR) and autophagy, and induces programmed cell death …

Genetic, developmental, biochemical, and environmental variables interact intricately to
produce sex differences. The significance of sex differences in cancer susceptibility is being …

BACKGROUND & AIMS: Metabolic syndrome (MetS), in which a non-classic feature is an
increase in systemic oxidative biomarkers, presents a high risk of diabetes and …

The mitochondria have a fundamental role in both cellular energy supply and oxidative
stress regulation and are target of the effects of sex steroids, particularly the neuroprotective …

BACKGROUND: A sexual dimorphism in human life expectancy has existed in almost every
country for as long as records have been kept. Although human life expectancy has …

Uncoupling proteins (UCPs) belong to a large family of mitochondrial solute carriers 25
(SLC25s) localized at the inner mitochondrial membrane. UCPs transport protons directly …

During ischemic stroke, neurons and glia are subjected to damage during the acute and
neuroinflammatory phases of injury. Production of reactive oxygen species (ROS) from …

Reactive oxygen species (ROS) is a term that defines a group of unstable compounds
derived from exogenous sources or endogenous metabolism. Under physiological …