Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

Repeated turnovers keep sex chromosomes young in willows

D Wang, Y Li, M Li, W Yang, X Ma, L Zhang, Y Wang… - Genome Biology, 2022 - Springer
Background Salicaceae species have diverse sex determination systems and frequent sex
chromosome turnovers. However, compared with poplars, the diversity of sex determination …

A comprehensive review of artificial intelligence for pharmacology research

B Li, K Tan, AR Lao, H Wang, H Zheng… - Frontiers in Genetics, 2024 - frontiersin.org
With the innovation and advancement of artificial intelligence, more and more artificial
intelligence techniques are employed in drug research, biomedical frontier research, and …

A chromosome‐level Populus qiongdaoensis genome assembly provides insights into tropical adaptation and a cryptic turnover of sex determination

Y Li, D Wang, W Wang, W Yang, J Gao… - Molecular …, 2023 - Wiley Online Library
Populus species have long been used as model organisms to study the adaptability of trees
and the evolution of sex chromosomes. As a species belonging to the section Populus and …

Developing a physiological signal-based, mean threshold and decision-level fusion algorithm (PMD) for emotion recognition

Q Zhang, H Zhang, K Zhou… - Tsinghua Science and …, 2023 - ieeexplore.ieee.org
With the development of computers, artificial intelligence, and cognitive science,
engagement in deep communication between humans and computers has become …

Transcriptional landscape of highly lignified poplar stems at single-cell resolution

Y Chen, S Tong, Y Jiang, F Ai, Y Feng, J Zhang, J Gong… - Genome biology, 2021 - Springer
Background Plant secondary growth depends on the activity of the vascular cambium, which
produces xylem and phloem. Wood derived from xylem is the most abundant form of …

[HTML][HTML] MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction

L Zhang, L Zhang, Y Guo, M Xiao, L Feng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Mitotic catastrophe (MC) is a form of programmed cell death induced by mitotic process
disorders, which is very important in tumor prevention, development, and drug resistance …

PtoWRKY40 interacts with PtoPHR1-LIKE3 while regulating the phosphate starvation response in poplar

N Chen, S Tong, J Yang, J Qin, W Wang… - Plant …, 2022 - academic.oup.com
Plants usually suffer from phosphorus starvation because of the low inorganic phosphate
(Pi) status of most soils. To cope with this, plants have evolved an adaptive phosphate …

PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar

S Tong, Y Wang, N Chen, D Wang, B Liu, W Wang… - Genome Biology, 2022 - Springer
Background Sensing and responding to stresses determine the tolerance of plants to
adverse environments. The triploid Chinese white poplar is widely cultivated in North China …

A genome assembly for Orinus kokonorica provides insights into the origin, adaptive evolution and further diversification of two closely related grass genera

K Qu, A Liu, M Yin, W Mu, S Wu, H Hu, J Chen… - Communications …, 2023 - nature.com
Ancient whole-genome duplication (WGD) or polyploidization is prevalent in plants and has
played a crucial role in plant adaptation. However, the underlying genomic basis of …