PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer
C Garlanda, B Bottazzi, E Magrini… - Physiological …, 2018 - journals.physiology.org
Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern
recognition molecule conserved in evolution which acts as a key component of humoral …
recognition molecule conserved in evolution which acts as a key component of humoral …
The long pentraxin PTX3 as a link between innate immunity, tissue remodeling, and cancer
A Doni, M Stravalaci, A Inforzato, E Magrini… - Frontiers in …, 2019 - frontiersin.org
The innate immune system comprises a cellular and a humoral arm. Humoral pattern
recognition molecules include complement components, collectins, ficolins, and pentraxins …
recognition molecules include complement components, collectins, ficolins, and pentraxins …
[HTML][HTML] PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma
GS Netti, G Lucarelli, F Spadaccino… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Abstract Pentraxin-3 (PTX3) belongs to the pentraxine family, innate immune regulators
involved in angiogenesis, proliferation and immune escape in cancer. Here, we evaluated …
involved in angiogenesis, proliferation and immune escape in cancer. Here, we evaluated …
The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling
B Bottazzi, A Inforzato, M Messa, M Barbagallo… - Journal of …, 2016 - Elsevier
Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in
evolution and characterized by a cyclic multimeric structure. C-reactive protein (CRP) and …
evolution and characterized by a cyclic multimeric structure. C-reactive protein (CRP) and …
The basic characteristics of the pentraxin family and their functions in tumor progression
Z Wang, X Wang, H Zou, Z Dai, S Feng… - Frontiers in …, 2020 - frontiersin.org
The pentraxin is a superfamily of proteins with the same domain known as the pentraxin
domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive …
domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive …
Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway
Cutaneous melanoma is one of the most aggressive cancers characterized by a high
plasticity, a propensity for metastasis, and drug resistance. Melanomas are composed of …
plasticity, a propensity for metastasis, and drug resistance. Melanomas are composed of …
[HTML][HTML] Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role
Abstract Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase
protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 …
protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 …
Pentraxins in the activation and regulation of innate immunity
Humoral fluid phase pattern recognition molecules (PRM s) are a key component of the
activation and regulation of innate immunity. Humoral PRM s are diverse. We focused on the …
activation and regulation of innate immunity. Humoral PRM s are diverse. We focused on the …
Long pentraxin 3: A novel multifaceted player in cancer
Since its discovery in 1992, long pentraxin 3 (PTX3) has been characterized as soluble
patter recognition receptor, a key player of the innate immunity arm with non-redundant …
patter recognition receptor, a key player of the innate immunity arm with non-redundant …
[HTML][HTML] Pentraxin 3 overexpression accelerated tumor metastasis and indicated poor prognosis in hepatocellular carcinoma via driving epithelial-mesenchymal …
T Song, C Wang, C Guo, Q Liu, X Zheng - Journal of Cancer, 2018 - ncbi.nlm.nih.gov
As a pattern recognition receptor, pentraxin 3 (PTX3) has been found to exert the pleiotropic
roles on a variety of cancers. However, the accurate clinical significance of PTX3 in …
roles on a variety of cancers. However, the accurate clinical significance of PTX3 in …