[PDF][PDF] Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs
M Asai, Y Li, SM Newton, BD Robertson… - FEMS Microbiology …, 2023 - academic.oup.com
Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …
disease models, due to ease of use and the presence of an innate immune system …
Recent advancements in the development of anti-tuberculosis drugs
S Chetty, M Ramesh, A Singh-Pillay… - Bioorganic & medicinal …, 2017 - Elsevier
Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population
of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments …
of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments …
Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance
H Safi, P Gopal, S Lingaraju, S Ma… - Proceedings of the …, 2019 - National Acad Sciences
The length and complexity of tuberculosis (TB) therapy, as well as the propensity of
Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB …
Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB …
Common variants in the glycerol kinase gene reduce tuberculosis drug efficacy
Despite the administration of multiple drugs that are highly effective in vitro, tuberculosis (TB)
treatment requires prolonged drug administration and is confounded by the emergence of …
treatment requires prolonged drug administration and is confounded by the emergence of …
Pyrazinamide triggers degradation of its target aspartate decarboxylase
P Gopal, JP Sarathy, M Yee, P Ragunathan… - Nature …, 2020 - nature.com
Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and
biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the …
biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the …
A biochemically-interpretable machine learning classifier for microbial GWAS
Current machine learning classifiers have successfully been applied to whole-genome
sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they …
sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they …
Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery
Tuberculosis is a global health dilemma. In 2016, the WHO reported 10.4 million incidences
and 1.7 million deaths. The need to develop new treatments for those infected with …
and 1.7 million deaths. The need to develop new treatments for those infected with …
Acid fasting: modulation of Mycobacterium tuberculosis metabolism at acidic pH
JJ Baker, SJ Dechow, RB Abramovitch - Trends in microbiology, 2019 - cell.com
Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …