Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

The various non-standard schedules required of shift workers force abrupt changes in the
timing of sleep and light-dark exposure. These changes result in disturbances of the …

Using a longitudinal dataset linking biometric and survey data from several cohorts of young
adults before and during the COVID-19 pandemic (N= 682), we document large disruptions …

Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Circadian Mechanisms in Medicine Molecular insights into diurnal variations in human
physiology and behavior are extending our understanding of a wide range of disease …

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Sleep disturbance is the most prominent symptom in depressive patients and was formerly
regarded as a main secondary manifestation of depression. However, many longitudinal …

Over the last 50 years, the concept of stress has evolved significantly, and our
understanding of the underlying neurobiology has expanded dramatically. Rather than …

INTRODUCTION The interaction among cell-autonomous circadian oscillators—daily cycles
of activity–rest and feeding–fasting—produces diurnal rhythms in gene expression in almost …

Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …