Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

Nonribosomal peptide synthetases (NRPSs) are incredible macromolecular machines that
produce a wide range of biologically-and therapeutically-relevant molecules. During …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …

Covering: up to September 2009 This review covers the recent literature on the release
mechanisms for polyketides and nonribosomal peptides produced by microorganisms. The …

Covering: up to January, 2014 We focus here on β-amino acids as components of complex
natural products because the presence of β-amino acids produces structural diversity in …

Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

Azaserine, a natural product containing a diazo group, exhibits anticancer activity. In this
study, we investigated the biosynthetic pathway to azaserine. The putative azaserine …