Pharmacodynamic parameters of pharmacokinetic/pharmacodynamic (PK/PD) integration models

L Zhang, H Xie, Y Wang, H Wang, J Hu… - Frontiers in Veterinary …, 2022 - frontiersin.org
Pharmacokinetic/pharmacodynamic (PK/PD) integration models are used to investigate the
antimicrobial activity characteristics of drugs targeting pathogenic bacteria through …

Antifungal Activity of a Medical-Grade Honey Formulation against Candida auris

T de Groot, T Janssen, D Faro, NAJ Cremers… - Journal of Fungi, 2021 - mdpi.com
Candida auris is a pathogenic yeast causing outbreaks in intensive care units with high
mortality rates. The treatment of C. auris colonization is challenging due to high resistance …

Navigating collateral sensitivity: insights into the mechanisms and applications of antibiotic resistance trade-offs

HA Mahmud, CA Wakeman - Frontiers in Microbiology, 2024 - frontiersin.org
The swift rise of antibiotic resistance, coupled with limited new antibiotic discovery, presents
a significant hurdle to global public health, demanding innovative therapeutic solutions …

[HTML][HTML] Collateral sensitivity between tetracyclines and aminoglycosides constrains resistance evolution in carbapenem-resistant Klebsiella pneumoniae

X Ma, W Xi, D Yang, L Zhao, W Yu, Y He, W Ni… - Drug Resistance …, 2023 - Elsevier
Aims The acquisition of resistance to one antibiotic may confer an increased sensitivity to
another antibiotic in bacteria, which is an evolutionary trade-off between different resistance …

Effect of Antibiotic Exposure on Staphylococcus epidermidis Responsible for Catheter-Related Bacteremia

C Pouget, C Chatre, JP Lavigne, A Pantel… - International Journal of …, 2023 - mdpi.com
Coagulase-negative staphylococci (CoNS) and especially Staphylococcus epidermidis are
responsible for health care infections, notably in the presence of foreign material (eg …

The evolution of resistance to synergistic multi‐drug combinations is more complex than evolving resistance to each individual drug component

NA Lozano‐Huntelman, A Bullivant… - Evolutionary …, 2023 - Wiley Online Library
Multidrug antibiotic resistance is an urgent public health concern. Multiple strategies have
been suggested to alleviate this problem, including the use of antibiotic combinations and …

Systematic investigation of resistance evolution to common antibiotics reveals conserved collateral responses across common human pathogens

MC Rodriguez de Evgrafov, M Faza… - Antimicrobial agents …, 2020 - Am Soc Microbiol
As drug resistance continues to grow, treatment strategies that turn resistance into a
disadvantage for the organism will be increasingly relied upon to treat infections and to …

Meropenem MICs at Standard and High Inocula and Mutant Prevention Concentration Inter-Relations: Comparative Study with Non-Carbapenemase-Producing and …

MV Golikova, EN Strukova, KN Alieva, VA Ageevets… - Antibiotics, 2023 - mdpi.com
The minimal inhibitory concentration (MIC) is conventionally used to define in vitro levels of
susceptibility or resistance of a specific bacterial strain to an antibiotic and to predict its …

Bayesian network modeling of patterns of antibiotic cross-resistance by bacterial sample source

SS Cherny, M Chowers, U Obolski - Communications Medicine, 2023 - nature.com
Background Antimicrobial resistance is a major healthcare burden, aggravated when it
extends to multiple drugs. While cross-resistance is well-studied experimentally, it is not the …

Alteration of adeS Contributes to Tigecycline Resistance and Collateral Sensitivity to Sulbactam in Acinetobacter baumannii

Y Yang, X Liu, D Zhou, J He, Q Chen, Q Xu… - Microbiology …, 2023 - Am Soc Microbiol
The treatment of extensively drug-resistant (XDR) A. baumannii has emerged as a major
problem. Tigecycline (TGC) and sulbactam (SUL) are both effective antibiotics against XDR …