Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health
benefits including improved metabolism, cardioprotection, and cancer prevention. Much of …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Extensive documentation has validated the role of UV irradiation as a tumor initiator and
promoter, inducing both squamous and basal cell carcinomas. Human epidermis is a tissue …

The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an
inherited syndrome of colon cancer predisposition known as familial adenomatous …

Curcumin, the major yellow pigment in turmeric, prevents the development of adenomas in
the intestinal tract of the C57Bl/6J Min/+ mouse, a model of human familial APC. To aid the …

A considerable amount of evidence collected from several different experimental systems
indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large …

Nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit colorectal tumorigenesis and are
among the few agents known to be useful for the chemoprevention of neoplasia. Here, we …

ContextEpidemiological studies have implicated the inducible form of cyclooxygenase (COX-
2) in the pathogenesis of colorectal cancer; however, its role is not fully understood …

Two isoforms of cyclooxygenase (COX) are known, and to date most studies have implicated
COX-2, rather than COX-1, as the isoform involved in colon carcinogenesis. In the present …

The development of colorectal cancer, one of the most frequent cancers, is influenced by
prostaglandins and fatty acids 1. Decreased prostaglandin production, seen in mice with …