Lipid-mediated signalling regulates a plethora of physiological processes, including crucial
aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in …

The prevalence of Alzheimer's disease, a chronic neurodegenerative condition, is
increasing as is the need for effective treatments and preventions. The underlying pathology …

In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Clusterin, also known as apolipoprotein J, is a versatile chaperone molecule which contains
several amphipathic and coiled-coil α-helices, typical characteristics of small heat shock …

ATP-binding cassette transporter A1 (ABCA1) is a cholesterol transporter that transfers
excess cellular cholesterol onto lipid-poor apolipoproteins. Given its critical role in …

It is generally believed that cholesterol homoeostasis in the brain is both linked to and
impacted by Alzheimer's disease (AD). For example, elevated levels of cholesterol in …

Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and
cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE …

Dementia is one of the major causes of disability in later life, and ischemic heart disease is a
leading cause of morbidity and mortality. Apolipoprotein E (apoE) plays a pivotal role in …