Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

The ATP–adenosine pathway functions as a key modulator of innate and adaptive immunity
within the tumour microenvironment. Consequently, multiple clinical strategies are being …

Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …

Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the
colonic host-microbe interactions that help maintain gut homeostasis. However, the precise …

The gasdermins are a family of pore-forming proteins recently implicated in the immune
response. One of these proteins, gasdermin D (GSDMD), has been identified as the …