Genetic variation and sickle cell disease severity: a systematic review and meta-analysis
Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …
Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease
V Labarque, EC Okocha - International Journal of Molecular Sciences, 2024 - mdpi.com
Sickle cell nephropathy (SCN) is a common complication of sickle cell disease (SCD) that
significantly contributes to morbidity and mortality. In addition to clinical and life-style factors …
significantly contributes to morbidity and mortality. In addition to clinical and life-style factors …
Genome-wide meta-analysis identifies new candidate genes for sickle cell disease nephropathy
ME Garrett, KL Soldano, KN Erwin, Y Zhang… - Blood …, 2023 - ashpublications.org
Sickle cell disease nephropathy (SCDN), a common SCD complication, is strongly
associated with mortality. Polygenic risk scores calculated from recent transethnic meta …
associated with mortality. Polygenic risk scores calculated from recent transethnic meta …