[HTML][HTML] Role of the PD-1 pathway in the immune response

LV Riella, AM Paterson, AH Sharpe… - American Journal of …, 2012 - Elsevier
Understanding immunoregulatory mechanisms is essential for the development of novel
interventions to improve long-term allograft survival. Programmed death 1 (PD-1) and its …

Tolerogenic dendritic cells in solid organ transplantation: where do we stand?

E Marín, MC Cuturi, A Moreau - Frontiers in immunology, 2018 - frontiersin.org
Over the past century, solid organ transplantation has been improved both at a surgical and
postoperative level. However, despite the improvement in efficiency, safety, and survival, we …

Tolerogenic dendritic cells: the pearl of immunotherapy in organ transplantation

Q Zhuang, H Cai, Q Cao, Z Li, S Liu, Y Ming - Frontiers in Immunology, 2020 - frontiersin.org
Over a half century, organ transplantation has become an effective method for the treatment
of end-stage visceral diseases. Although the application of immunosuppressants (IS) …

Targeting PD-1/PD-L1 inhibits rejection in a heterotopic tracheal allograft model of lung transplantation

T Kaiho, H Suzuki, A Hata, H Matsumoto… - Frontiers in …, 2023 - frontiersin.org
Immune checkpoint molecules such as programmed death-1 (PD-1) and programmed death
ligand-1 (PD-L1) have revolutionized the field of lung cancer treatment. As part of our study …

Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation

E Yao, G Zhang, J Huang, X Yang… - Journal of Cellular …, 2019 - Wiley Online Library
Oleoylethanolamide (OEA) is an endogenous lipid mediator involved in the control of
feeding, body weight, and energy metabolism. However, whether OEA modulates …

Fine-tuning tumor-and allo-immunity: advances in the use of immune checkpoint inhibitors in kidney transplant recipients

T Van Meerhaeghe, N Murakami… - Clinical Kidney …, 2024 - academic.oup.com
Cancer is a common complication after kidney transplantation. Kidney transplant recipients
(KTR) have a 2-to 4-fold higher risk of developing cancer compared to the general …

[HTML][HTML] Early tumor-infiltrating dendritic cells change their characteristics drastically in association with murine melanoma progression

T Nakahara, J Oba, C Shimomura… - Journal of Investigative …, 2016 - Elsevier
Dendritic cells (DCs) have a critical effect on the outcome of adaptive immune responses
against growing tumors. Tumor-infiltrating dendritic cells (TIDCs) play diverse roles in the …

Ex vivo anchored PD‐L1 functionally prevent in vivo renal allograft rejection

Z Luo, T Liao, Y Zhang, H Zheng, Q Sun… - Bioengineering & …, 2022 - Wiley Online Library
Organ transplantation is the optimal treatment for patients with end‐stage diseases. T cell
activation is a major contributing factor toward the trigger of rejection. Induction therapy with …

Rejection and regulation: a tight balance

IF Ashoor, N Najafian - Current Opinion in Organ Transplantation, 2012 - journals.lww.com
The balance of effector and regulatory mechanisms contributing to allograft outcome is very
complex. It is likely that targeting multiple pathways will be required to achieve tolerance …

Adoptive transfusion of tolerant dendritic cells prolong the survival of renal allografts: a systematic review

MJ Xia, J Shan, YP Li, YN Zhou, YJ Guo… - Journal of Evidence …, 2013 - Wiley Online Library
Objective The aim of this study was to systematically review the effects of transfusing Tol‐
DCs induced by different methods on renal transplantation and survival time. Method …