Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Mitochondrial movements are tightly controlled to maintain energy homeostasis and prevent
oxidative stress. Miro is an outer mitochondrial membrane protein that anchors mitochondria …

Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive
inherited Parkinson's disease (PD). We have exploited our recent discovery that …

Cells keep their energy balance and avoid oxidative stress by regulating mitochondrial
movement, distribution, and clearance. We report here that two Parkinson's disease …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

Mitochondrial dysfunction and perturbed degradation of proteins have been implicated in
Parkinson's disease (PD) pathogenesis. Mutations in the Parkin and PINK1 genes are a …

Mitochondria sustain damage with aging, and the resulting mitochondrial dysfunction has
been implicated in a number of diseases including Parkinson disease. We recently …

A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …

Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-
promoting proteins that mediate mitochondrial dynamism are highly expressed in, and …