Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

Fifteen years ago, cell lineage restriction boundaries were discovered in the embryonic
vertebrate hindbrain, subdividing it into a series of cell-tight compartments (known as …

The cerebellum is one of the best studied parts of the brain. The cerebellar cortex is
composed of four main types of neurons: granule cells, Purkinje cells, and two types of …

Brain structures derived from the mesencephalon (mes) and rhombomere 1 (r1) modulate
distinct motor and sensory modalities. The precise origin and cellular behaviors …

The ciliopathy Joubert syndrome is marked by cerebellar vermis hypoplasia, a phenotype for
which the pathogenic mechanism is unclear,,. To investigate Joubert syndrome …

We applied single-cell RNA sequencing to profile genome-wide gene expression in about
9400 individual cerebellar cells from the mouse embryo at embryonic day 13.5. Reiterative …

During embryogenesis, the isthmic organizer, a well-described signaling center at the
junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior …

The molecular control of cell-type specification within the developing cerebellum as well as
the genetic causes of the most common human developmental cerebellar disorders have …

Over the last 60 years, the spotlight of research has periodically returned to the cerebellum
as new techniques and insights have emerged. Because of its simple homogeneous …