Emerging mechanisms of obesity-associated immune dysfunction
SR Shaikh, MA Beck, Y Alwarawrah… - Nature Reviews …, 2024 - nature.com
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus,
cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also …
cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also …
Targeted application of functional foods as immune fitness boosters in the defense against viral infection
In recent times, the emergence of viral infections, including the SARS-CoV-2 virus, the
monkeypox virus, and, most recently, the Langya virus, has highlighted the devastating …
monkeypox virus, and, most recently, the Langya virus, has highlighted the devastating …
SARS-CoV-2 infects adipose tissue in a fat depot-and viral lineage-dependent manner
TD Saccon, F Mousovich-Neto, RG Ludwig… - Nature …, 2022 - nature.com
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue
infection and disease progression has been proposed. Here we demonstrate that SARS …
infection and disease progression has been proposed. Here we demonstrate that SARS …
A potential association between obesity and reduced effectiveness of COVID‐19 vaccine‐induced neutralizing humoral immunity
Due to the adverse effects of obesity on host immunity, this study investigated the
effectiveness of COVID‐19 vaccines (BNT162b2, ChAdOx‐nCov‐2019, and mRNA‐1273) in …
effectiveness of COVID‐19 vaccines (BNT162b2, ChAdOx‐nCov‐2019, and mRNA‐1273) in …
[HTML][HTML] Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation
Respiratory viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) and influenza A virus (IAV) trigger distinct clinical outcomes defined by immunity …
CoV-2) and influenza A virus (IAV) trigger distinct clinical outcomes defined by immunity …
Obesity dysregulates the immune response to influenza infection and vaccination through metabolic and inflammatory mechanisms
SR Shaikh, NJ MacIver, MA Beck - Annual review of nutrition, 2022 - annualreviews.org
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …
Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase
H Jiang, Z Zhang - Virology Journal, 2023 - Springer
Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction
of the innate immune response to influenza virus infection results in hypercytokinemia …
of the innate immune response to influenza virus infection results in hypercytokinemia …
COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA. 1 infection in diet-induced obese mice through boosting host innate antiviral responses
Background Obesity is a worldwide epidemic and is considered a risk factor of severe
manifestation of Coronavirus Disease 2019 (COVID-19). The pathogenicity of severe acute …
manifestation of Coronavirus Disease 2019 (COVID-19). The pathogenicity of severe acute …
Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations
Vaccine efficacy determined within the controlled environment of a clinical trial is usually
substantially greater than real-world vaccine effectiveness. Typically, this results from …
substantially greater than real-world vaccine effectiveness. Typically, this results from …
Inflammatory cell death: how macrophages sense neighbouring cell infection and damage
X Wang, LI Labzin - Biochemical Society Transactions, 2023 - portlandpress.com
Programmed cell death is a critical host defence strategy during viral infection. Neighbouring
cells deal with this death in distinct ways depending on how the infected cell dies. While …
cells deal with this death in distinct ways depending on how the infected cell dies. While …