Emerging mechanisms of obesity-associated immune dysfunction

SR Shaikh, MA Beck, Y Alwarawrah… - Nature Reviews …, 2024 - nature.com
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus,
cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also …

Targeted application of functional foods as immune fitness boosters in the defense against viral infection

D Finnegan, R Tocmo, C Loscher - Nutrients, 2023 - mdpi.com
In recent times, the emergence of viral infections, including the SARS-CoV-2 virus, the
monkeypox virus, and, most recently, the Langya virus, has highlighted the devastating …

SARS-CoV-2 infects adipose tissue in a fat depot-and viral lineage-dependent manner

TD Saccon, F Mousovich-Neto, RG Ludwig… - Nature …, 2022 - nature.com
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue
infection and disease progression has been proposed. Here we demonstrate that SARS …

A potential association between obesity and reduced effectiveness of COVID‐19 vaccine‐induced neutralizing humoral immunity

AA Faizo, FS Qashqari, SA El‐Kafrawy… - Journal of Medical …, 2023 - Wiley Online Library
Due to the adverse effects of obesity on host immunity, this study investigated the
effectiveness of COVID‐19 vaccines (BNT162b2, ChAdOx‐nCov‐2019, and mRNA‐1273) in …

[HTML][HTML] Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation

J Yunis, KR Short, D Yu - Trends in Microbiology, 2023 - cell.com
Respiratory viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) and influenza A virus (IAV) trigger distinct clinical outcomes defined by immunity …

Obesity dysregulates the immune response to influenza infection and vaccination through metabolic and inflammatory mechanisms

SR Shaikh, NJ MacIver, MA Beck - Annual review of nutrition, 2022 - annualreviews.org
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …

Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase

H Jiang, Z Zhang - Virology Journal, 2023 - Springer
Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction
of the innate immune response to influenza virus infection results in hypercytokinemia …

COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA. 1 infection in diet-induced obese mice through boosting host innate antiviral responses

Y Chen, W Song, C Li, J Wang, F Liu, Z Ye, P Ren… - …, 2023 - thelancet.com
Background Obesity is a worldwide epidemic and is considered a risk factor of severe
manifestation of Coronavirus Disease 2019 (COVID-19). The pathogenicity of severe acute …

Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations

RA Purcell, RM Theisen, KB Arnold… - Frontiers in …, 2023 - frontiersin.org
Vaccine efficacy determined within the controlled environment of a clinical trial is usually
substantially greater than real-world vaccine effectiveness. Typically, this results from …

Inflammatory cell death: how macrophages sense neighbouring cell infection and damage

X Wang, LI Labzin - Biochemical Society Transactions, 2023 - portlandpress.com
Programmed cell death is a critical host defence strategy during viral infection. Neighbouring
cells deal with this death in distinct ways depending on how the infected cell dies. While …