Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …

Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …

Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in
metabolic diseases such as type 2 diabetes. We report here that IR is incorporated into …

Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

Protein recruitment to DNA break sites is an integral part of the DNA damage response
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …

Biliary tract cancer (BTC) is the second most common primary liver cancer after
hepatocellular carcinoma and accounts for 2% of cancer-related deaths. BTCs are classified …

The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been
recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Protein-protein and protein-RNA interactions are essential for cell function and survival.
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …

The probability of a given receptor tyrosine kinase (RTK) triggering a defined cellular
outcome is low because of the promiscuous nature of signalling, the randomness of …