An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019 …

CA Devaux, L Camoin-Jau - Frontiers in microbiology, 2022 - frontiersin.org
It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell
surface enzyme involved in the regulation of blood pressure. More recently, it was proven …

Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?

M Montanari, B Canonico, E Nordi, D Vandini… - Advances in Biological …, 2021 - Elsevier
The article describes the possible pathophysiological origin of COVID-19 and the crucial
role of renin-angiotensin system (RAS), providing several “converging” evidence in support …

COVID-19 infection in pregnancy: obstetrical risk factors and neonatal outcomes—a monocentric, single-cohort study

A Vimercati, R De Nola, P Trerotoli, ME Metta… - Vaccines, 2022 - mdpi.com
The effects of coronavirus disease 2019 caused by severe acute respiratory syndrome
coronavirus 2 on pregnant women and neonates are mainly unknown, since limited data are …

Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages

U Zankharia, A Yadav, Y Yi, BH Hahn… - Journal of Leukocyte …, 2022 - academic.oup.com
Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV2), which causes the
disease COVID-19, has caused an unprecedented global pandemic. Angiotensin-converting …

Moderate exercise may prevent the development of severe forms of COVID-19, whereas high-intensity exercise may result in the opposite

BA Hagiu - Medical hypotheses, 2021 - Elsevier
Sedentary lifestyle increases the risk of hospitalization for COVID-19 independently of other
factors. There is enough statistics to show that exercise prevents severe forms of COVID-19 …

Performance of immunoglobulin G serology on finger prick capillary dried blood spot samples to detect a SARS-CoV-2 antibody response

AM Nikiforuk, B McMillan, SR Bartlett… - Microbiology …, 2022 - Am Soc Microbiol
We investigate the diagnostic accuracy and predictive value of finger prick capillary dried
blood spot (DBS) samples tested by a quantitative multiplex anti-immunoglobulin G (IgG) …

Polymorphisms within the SARS-CoV-2 human receptor genes associate with variable disease outcomes across ethnicities

T Adimulam, T Arumugam, A Naidoo, K Naidoo… - Genes, 2023 - mdpi.com
The contribution of human genes to the variability of disease outcomes has been shown to
be important across infectious diseases. Studies have shown mutations within specific …

Nasopharyngeal expression of angiotensin-converting enzyme 2 and transmembrane serine protease 2 in children within SARS-CoV-2-infected family clusters

MR Hasan, MN Ahmad, SR Dargham… - Microbiology …, 2021 - Am Soc Microbiol
Lower levels of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine
protease 2 (TMPRSS2) in the nasal epithelium of children may be related to a lower …

A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS‐CoV‐2 Spike Protein Activation

J Sarker, P Das, S Sarker, AK Roy, AZMR Momen - Scientifica, 2021 - Wiley Online Library
SARS‐CoV‐2, the coronavirus responsible for the COVID‐19 pandemic, uses the host cell
membrane receptor angiotensin‐converting enzyme 2 (ACE2) for anchoring its spike …

Association Between ACE2 and Lung Diseases

C Su, C Li, X Hu, J Wang, L Liu, X Zhang… - Infection and Drug …, 2024 - Taylor & Francis
Abstract Angiotensin-converting enzyme 2 (ACE2) is an important regulator of the Renin-
Angiotensin System (RAS). Additionally, it has been identified as a functional receptor for the …