Physical exercise represents a major challenge to whole-body homeostasis, provoking
acute and adaptative responses at the cellular and systemic levels. Different sources of …

At physiological concentrations, reactive oxygen species (ROS), including superoxide
anions and H 2 O 2, are considered as second messengers that play key roles in cellular …

DUOX1, an NADPH oxidase family member, catalyzes the production of hydrogen peroxide.
DUOX1 is expressed in various tissues, including the thyroid and respiratory tract, and plays …

Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis.
Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD) …

NOX/DUOX enzymes are transmembrane proteins that carry electrons through biological
membranes generating reactive oxygen species. The NOX family is composed of seven …

Purpose The objectives of this study were to analyze the distribution of dual oxidase (DUOX)
system genes (containing DUOX2, DUOX1, DUOXA2, and DUOXA1) variants in children …

Inborn defects in thyroid hormone biosynthesis contribute to nearly half of congenital
hypothyroidism (CH) cases in China. The thyroid peroxidase (TPO) mutation is one of the …

Background: Congenital hypothyroidism (CH) is a common metabolic disorder in children
that can impact growth and neurodevelopment, particularly during infancy and early …

Thyroid hormone synthesis requires H 2 O 2, produced by two NADPH oxidases, Duox1 and
Duox2. To be fully active at the apical pole of the thyrocytes, these enzymes need additional …

Mucosal epithelial cells act as the first immunologic barrier of organisms, and contact directly
with pathogens. Therefore, hosts must have differential strategies to combat pathogens …