[HTML][HTML] Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

G Tezel - Progress in retinal and eye research, 2022 - Elsevier
Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

A Biţă, IR Scorei, MV Ciocîlteu, OE Nicolaescu… - Molecules, 2023 - mdpi.com
Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

From bench to behaviour: The role of lifestyle factors on intraocular pressure, neuroprotection, and disease progression in glaucoma

A Kumar, Y Ou - Clinical & experimental ophthalmology, 2023 - Wiley Online Library
Current glaucoma management centres on intraocular pressure (IOP) reduction through
pharmacological and surgical therapy. Despite broad interest in active management of …

Association between daily niacin intake and glaucoma: National Health and Nutrition Examination Survey

T Taechameekietichai, S Chansangpetch… - Nutrients, 2021 - mdpi.com
Background and Aims: To determine the relationship between dietary intake of niacin and
glaucoma using the data from the 2005 to 2008 National Health and Nutrition Examination …

New insights into metabolism dysregulation after TBI

HC Oft, DW Simon, D Sun - Journal of neuroinflammation, 2024 - Springer
Traumatic brain injury (TBI) remains a leading cause of death and disability that places a
great physical, social, and financial burden on individuals and the health system. In this …

Glaucoma: neuroprotection with NAD-based therapeutic interventions

A Chiarugi - Trends in Pharmacological Sciences, 2023 - cell.com
Clinical evidence shows that intraocular hypertension is not the primary pathogenetic event
of glaucoma, whereas early neurodegeneration of retinal ganglion cells (RGCs) represents …

NAD+ and Niacin Supplementation as Possible Treatments for Glaucoma and Age-Related Macular Degeneration: A Narrative Review

MR Gemae, MD Bassi, P Wang, EK Chin, DRP Almeida - Nutrients, 2024 - mdpi.com
Glaucoma and age-related macular degeneration (AMD) are progressive retinal diseases
characterized by increased oxidative stress, inflammation, and mitochondrial dysfunction …

[HTML][HTML] Nicotinamide: Bright Potential in Glaucoma Management

S Babighian, I Gattazzo, MS Zanella, A Galan… - Biomedicines, 2024 - mdpi.com
Background: Glaucoma is a major cause of incurable ocular morbidity and poses significant
challenges in its management due to the limited treatment options and potential adverse …

Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases

F Li, C Wu, G Wang - Neuroscience Bulletin, 2024 - Springer
As the aging population continues to grow rapidly, age-related diseases are becoming an
increasing burden on the healthcare system and a major concern for the well-being of …

Innate immunity dysregulation in aging eye and therapeutic interventions

S Das, Z Ahmad, A Suryawanshi, A Kumar - Ageing Research Reviews, 2022 - Elsevier
The prevalence of eye diseases increases considerably with age, resulting in significant
vision impairment. Although the pathobiology of age-related eye diseases has been studied …