Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application

T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

Stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells

S Takahashi, N Sugimoto - Chemical Society Reviews, 2020 - pubs.rsc.org
Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …

Chemical regulation of DNA i‐motifs for nanobiotechnology and therapeutics

M Debnath, K Fatma, J Dash - Angewandte Chemie, 2019 - Wiley Online Library
DNA sequences rich in cytosine have the propensity, under acidic pH, to fold into four‐
stranded intercalated DNA structures called i‐motifs. Recent studies have provided …

[HTML][HTML] In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells

P Víšková, E Ištvánková, J Ryneš, Š Džatko… - Nature …, 2024 - nature.com
I-Motifs (iM) are non-canonical DNA structures potentially forming in the accessible, single-
stranded, cytosine-rich genomic regions with regulatory roles. Chromatin, protein …

Systematic investigation of sequence requirements for DNA i-motif formation

P Školáková, D Renčiuk, J Palacký… - Nucleic Acids …, 2019 - academic.oup.com
The formation of intercalated motifs (iMs)—secondary DNA structures based on
hemiprotonated C. C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical …

DNA i-motif formation at neutral pH is driven by kinetic partitioning

P Školáková, M Gajarský, J Palacký… - Nucleic Acids …, 2023 - academic.oup.com
Cytosine-rich DNA regions can form four-stranded structures based on hemi-protonated C.
C+ pairs, called i-motifs (iMs). Using CD, UV absorption, NMR spectroscopy, and DSC …

Effects of Sequence and Base Composition on the CD and TDS Profiles of i‐DNA

N Iaccarino, M Cheng, D Qiu, B Pagano… - Angewandte Chemie …, 2021 - Wiley Online Library
The i‐motif DNA, also known as i‐DNA, is a non‐canonical DNA secondary structure formed
by cytosine‐rich sequences, consisting of two intercalated parallel‐stranded duplexes held …

AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation

JH Hur, CY Kang, S Lee, N Parveen, J Yu… - Nucleic Acids …, 2021 - academic.oup.com
I-motif or C4 is a four-stranded DNA structure with a protonated cytosine: cytosine base pair
(C+: C) found in cytosine-rich sequences. We have found that oligodeoxynucleotides …

Single-molecule analysis of i-motif within self-assembled DNA duplexes and nanocircles

A Megalathan, BD Cox, PD Wilkerson… - Nucleic Acids …, 2019 - academic.oup.com
The cytosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are
prevalent in genomic DNA. Recent studies of i-motif–forming sequences have shown …

[HTML][HTML] Tricky topology: persistence of folded human telomeric i-motif DNA at ambient temperature and neutral pH

MAS Abdelhamid, ZAE Waller - Frontiers in Chemistry, 2020 - frontiersin.org
i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held
together by hemi-protonated cytosine-cytosine base pairs. These structures have been …