Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate
and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This …

Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …

Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-
aminoquinoline antimalarials including chloroquine (CQ) but cannot fully explain the activity …

Using predictions from heme− quinoline antimalarial complex structures, previous
modifications of chloroquine (CQ), and hypotheses for chloroquine resistance (CQR), we …

The synthesis of the new compounds (7-chloroquinolin-4-yl)-N′-(1′-
dimethylaminomethylferrocen-1-ylmethyl)-amine (4a) and N-(7-chloroquinolin-4-yl)-N …

In the face of the recent pandemic and emergence of infectious diseases of viral origin,
research on parasitic diseases such as malaria continues to remain critical and innovative …

This chapter summarizes recent developments in the design, synthesis, and structure–
activity relationship studies of organometallic antimalarials. It begins with a general …

Among the infectious illnesses designated by the World Health Organization (WHO) as
neglected tropical diseases (NTDs), four illnesses are major health concerns in the …