Immunotherapy has achieved great success recently and opened a new avenue for anti-
tumor treatment. Programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) …

The drugs targeting the PD-1/PD-L1 pathway have gained abundant clinical applications for
cancer immunotherapy. However, only a part of patients benefit from such immunotherapy …

Nitrogen mustards (NMs) are an important class of chemotherapeutic drugs and have been
widely employed for the treatment of various cancers. However, due to the high reactivity of …

The PD-1/PD-L1 checkpoint pathway is important for regulating immune responses and can
be targeted by immunomodulatory drugs to treat a variety of immune disorders. However …

Abstract The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints
and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for …

Histone deacetylases (HDACs) are promising targets for the design of anticancer drugs.
HDAC6 is of particular interest since it is a cytoplasmic HDAC regulating the acetylation …

Primary cutaneous melanoma is the most lethal of all skin neoplasms and its incidence is
increasing. Clinical management of advanced melanoma in the last decade has been …

Computational approaches in immune-oncology therapies focus on using data-driven
methods to identify potential immune targets and develop novel drug candidates. In …

Inhibiting the PD-1/PD-L1 protein–protein interaction is a key immunotherapy for cancer.
Antibodies dominate the clinical space but are costly, with limited applicability and immune …

A cell membrane is an essential cellular component providing protection against the outer
environment. It is also a host for proteins and carbohydrates responsible for, eg transporter …