Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

NCX proteins explore the electrochemical gradient of Na+ to mediate Ca 2+-fluxes in
exchange with Na+ either in the Ca 2+-efflux (forward) or Ca 2+-influx (reverse) mode …

Calcium ion is a versatile messenger in many cell-signaling processes. To achieve their
functions, calcium-binding proteins selectively bind Ca2+ against a background of …

Isothermal titration calorimetry is a widely used biophysical technique for studying the
formation or dissociation of molecular complexes. Over the last 5 years, much work has …

The lanmodulin (LanM) protein has emerged as an effective means for rare earth element
(REE) extraction and separation from complex feedstocks without the use of organic …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

Na+/Ca2+ exchanger (NCX) proteins extrude Ca2+ from the cell to maintain cellular
homeostasis. Since NCX proteins contribute to numerous physiological and …

In eukaryotic Na+/Ca 2+ exchangers (NCX) the Ca 2+ binding CBD1 and CBD2 domains
form a two-domain regulatory tandem (CBD12). An allosteric Ca 2+ sensor (Ca3–Ca4 sites) …

Sodium–calcium exchanger (NCX) proteins are ubiquitously expressed and play a pivotal
role in cellular calcium homeostasis by mediating uphill calcium efflux across the cell …