Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine
thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

Abstract AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of
activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse …

A wide range of human diseases, including cancer, has a striking age-dependent onset.
However, the molecular mechanisms that connect aging and cancer are just beginning to be …

Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …

Mammalian target of rapamycin (mTOR) is a kinase that functions as a master switch
between catabolic and anabolic metabolism and as such is a target for the design of …

There has been considerable progress in the systemic treatment of cancer because of the
rapid development and clinical application of molecular targeted agents. Although patients …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

The mammalian target of rapamycin (mTOR) has drawn much attention recently because of
its essential role in cell growth control and its involvement in human tumorigenesis. Great …