Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Retinitis pigmentosa (RP) is an inherited condition that features degeneration of rod and
cone photoreceptors. In all forms of RP, the genetic mutation is expressed exclusively in …

The cone dysfunction syndromes are a heterogeneous group of inherited, predominantly
stationary retinal disorders characterised by reduced central vision and varying degrees of …

Retinitis pigmentosa (RP) is an inherited photoreceptor degenerative disorder that results in
blindness. The disease is often caused by mutations in genes that are specific to rod …

Cell-based therapeutics offer diverse options for treating retinal degenerative diseases, such
as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). AMD is …

Human X-linked blue-cone monochromacy (BCM), a disabling congenital visual disorder of
cone photoreceptors, is a candidate disease for gene augmentation therapy. BCM is caused …

Nucleocytoplasmic transport is an essential cellular activity and occurs via nuclear pore
complexes (NPCs) that reside in the double membrane of the nuclear envelope. Significant …

Nuclear pore complexes are multiprotein channels that span the nuclear envelope, which
connects the nucleus to the cytoplasm. In addition to their main role in the regulation of …

Purpose Achromatopsia (ACHM) is a congenital, autosomal recessive retinal disease that
manifests cone dysfunction, reduced visual acuity and color vision, nystagmus, and …

Acute necrotizing encephalopathy (ANE) is a devastating neurologic condition that can arise
following a variety of systemic infections, including influenza and SARS-CoV-2. Affected …