Macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases

J Dort, P Fabre, T Molina, NA Dumont - Stem cells international, 2019 - Wiley Online Library
Muscle regeneration is a closely regulated process that involves a variety of cell types such
as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory …

Immune-mediated pathology in Duchenne muscular dystrophy

AS Rosenberg, M Puig, K Nagaraju… - Science translational …, 2015 - science.org
Immunological and inflammatory processes downstream of dystrophin deficiency as well as
metabolic abnormalities, defective autophagy, and loss of regenerative capacity all …

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

DR Lemos, F Babaeijandaghi, M Low, CK Chang… - Nature medicine, 2015 - nature.com
Depending on the inflammatory milieu, injury can result either in a tissue's complete
regeneration or in its degeneration and fibrosis, the latter of which could potentially lead to …

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

D Ryu, H Zhang, ER Ropelle, V Sorrentino… - Science translational …, 2016 - science.org
Neuromuscular diseases are often caused by inherited mutations that lead to progressive
skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice …

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

O Contreras, FMV Rossi, M Theret - Skeletal Muscle, 2021 - Springer
Striated muscle is a highly plastic and regenerative organ that regulates body movement,
temperature, and metabolism—all the functions needed for an individual's health and well …

[HTML][HTML] Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease

W Chen, W You, TG Valencak, T Shan - Ageing Research Reviews, 2022 - Elsevier
Sarcopenia and myopathies cause progressive muscle weakness and degeneration, which
are closely associated with fat infiltration and fibrosis in muscle. Recently, experimental …

A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15

A Patsalos, L Halasz, MA Medina-Serpas… - Journal of Experimental …, 2021 - rupress.org
Muscle regeneration is the result of the concerted action of multiple cell types driven by the
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …

Redox control of skeletal muscle regeneration

E Le Moal, V Pialoux, G Juban… - Antioxidants & redox …, 2017 - liebertpub.com
Skeletal muscle shows high plasticity in response to external demand. Moreover, adult
skeletal muscle is capable of complete regeneration after injury, due to the properties of …

Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise‐induced muscle damage management

B Chazaud - Immunology and cell biology, 2016 - Wiley Online Library
Increase in the practice of sport by more and more numerous people in the Western
countries is associated with an increase in muscle injuries, and in demand for improving …