In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

The functional diversity of natural killer (NK) cell repertoires stems from differentiation,
homeostatic, receptor–ligand interactions and adaptive-like responses to viral infections. In …

Abstract Poly-ADP-ribose-polymerases (PARPs) 1 and 2 are nuclear enzymes that catalyze
the poly-ADP-ribosylation of nuclear proteins transferring poly-ADP-ribose (PAR) polymers …

The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely
associated with the centrosome during interphase. Conversely, the Golgi complex assumes …

While the number of patients diagnosed with neurodegenerative disorders like Alzheimer's
disease, amyotrophic lateral sclerosis, and Parkinson's disease is increasing, there are …

The Golgi complex occupies a strategic position in the endomembrane system and acts not
only as a key trafficking and sorting station and a vital biosynthetic center for glycoproteins …

Membrane fission is an essential cellular process by which continuous membranes split into
separate parts. We have previously identified CtBP1-S/BARS (BARS) as a key component of …

A promising new compound class for treating human malaria is the imidazolopiperazines
(IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against …

MUC16, precursor of the most widely used ovarian cancer biomarker CA125, is upregulated
in multiple malignancies and is associated with poor prognosis. While thepro-tumorigenic …