Broadening horizons: the role of ferroptosis in cancer
The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
GPX4 in cell death, autophagy, and disease
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
J Li, J Liu, Z Zhou, R Wu, X Chen, C Yu… - Science translational …, 2023 - science.org
Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …
[HTML][HTML] Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies
HJ Shields, A Traa, JM Van Raamsdonk - Frontiers in cell and …, 2021 - frontiersin.org
Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …
neurodegeneration and cancer. Despite decades of research dedicated to understanding …
Ferroptosis, radiotherapy, and combination therapeutic strategies
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …
The development of the concept of ferroptosis
T Hirschhorn, BR Stockwell - Free Radical Biology and Medicine, 2019 - Elsevier
The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …
The tumor suppressor protein p53 and the ferroptosis network
Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many
ways, from altering the activity of antioxidant enzymes to the level of transcription factors …
ways, from altering the activity of antioxidant enzymes to the level of transcription factors …
Healthful aging mediated by inhibition of oxidative stress
SF Vatner, J Zhang, M Oydanich, T Berkman… - Ageing Research …, 2020 - Elsevier
The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …
related to the accompanying burden of debilitating diseases prevalent in the older …
GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues
Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …
Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
aerobic metabolism, as a result of accidental electron leakage as well as regulated …