Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

Y Zhao, L Lin, Z Xiao, M Li, X Wu, W Li… - Journal of …, 2018 - Wiley Online Library
γδ T cells, a subgroup of T cells based on the γδ TCR, when compared with conventional T
cells (αβ T cells), make up a very small proportion of T cells. However, its various subgroups …

γδ T Cells Cross‐Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection

S Meraviglia, S El Daker, F Dieli… - Journal of …, 2011 - Wiley Online Library
Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is
mediated by interactions between specific T cells and activated antigen presenting cells. To …

Role of cytokines and chemokines in the regulation of innate immunity and HIV infection

M Alfano, G Poli - Molecular immunology, 2005 - Elsevier
The earliest defense against microbial infection is represented by the responses of the
innate (or natural) immune system, that also profoundly regulates the adaptive (or acquired) …

Проточная цитометрия в биомедицинских исследованиях

АВ Зурочка, СВ Хайдуков, ИВ Кудрявцев… - 2018 - elibrary.ru
В монографии изложены современные взгляды на применение проточной
цитофлуориметрии в норме и при различных патологических процессах. Приведена …

[HTML][HTML] Antiviral reactivities of γδ T cells

F Poccia, C Agrati, F Martini, MR Capobianchi… - Microbes and …, 2005 - Elsevier
The complex antiviral immune mechanisms involve both adaptive and innate reactions
mediated by γδ T lymphocytes, whose unique immunosurveillance contributions are …

Lack of CD27− CD45RA− Vγ9Vδ2+ T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis

C Gioia, C Agrati, R Casetti, C Cairo… - The Journal of …, 2002 - journals.aai.org
In humans, the circulating pool of mycobacteria-reactive Vγ9Vδ2+ T cells is expanded with
age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed …

Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood γδ T cells despite suppressive therapy

MA Poles, S Barsoum, W Yu, J Yu, P Sun… - Journal of …, 2003 - Am Soc Microbiol
ABSTRACT γδ T cells are primarily found in the gastrointestinal mucosa and play an
important role in the first line of defense against viral, bacterial, and fungal pathogens. We …

[HTML][HTML] Vγ2Vδ2+ T cells and anti-microbial immune responses

ZW Chen, NL Letvin - Microbes and infection, 2003 - Elsevier
Vγ2Vδ2+ T cells exist only in primates and constitute the majority of circulating human γδ T
cells. Recent studies have demonstrated that this unique γδ T cell subpopulation can be a …

γδ T‐cell responses during HIV infection and antiretroviral therapy

JA Juno, EM Eriksson - Clinical & translational immunology, 2019 - Wiley Online Library
HIV infection is associated with a rapid and sustained inversion of the Vδ1: Vδ2 T‐cell ratio
in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART …

Drug-induced expansion and differentiation of Vγ9Vδ2 T cells in vivo: the role of exogenous IL-2

R Casetti, G Perretta, A Taglioni, M Mattei… - The Journal of …, 2005 - journals.aai.org
Human Vγ9Vδ2 T cells recognize nonpeptidic Ags generated by the 1-deoxy-d-xylulose 5-
phosphate (many eubacteria, algae, plants, and Apicomplexa) and mevalonate (eukaryotes …