Molecular biology of osteosarcoma

AM Czarnecka, K Synoradzki, W Firlej, E Bartnik… - Cancers, 2020 - mdpi.com
Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

Molecular mechanism of ferroptosis in orthopedic diseases

L Gao, W Hua, L Tian, X Zhou, D Wang, Y Yang, G Ni - Cells, 2022 - mdpi.com
Ferroptosis is a new iron-dependent programmed cell death process that is directly
mediated by the accumulation of lipid peroxides and reactive oxygen species. Numerous …

[HTML][HTML] lncRNA SNHG10 promotes the proliferation and invasion of osteosarcoma via wnt/β-catenin signaling

S Zhu, Y Liu, X Wang, J Wang, G Xi - Molecular Therapy-Nucleic Acids, 2020 - cell.com
Uncontrolled growth and an enforced epithelial-mesenchymal transition (EMT) process
contribute to the poor survival rate of patients with osteosarcoma (OS). Long noncoding …

[HTML][HTML] Targeting ferroptosis in osteosarcoma

J Zhao, Y Zhao, X Ma, B Zhang, H Feng - Journal of bone oncology, 2021 - Elsevier
Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents,
with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non …

[HTML][HTML] Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells

H Jin, X Jin, H Zhang, W Wang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are a novel class of non-coding RNA which have recently shown
huge capabilities in the regulation of gene expression at the post-transcriptional level …

MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma

B Otoukesh, M Abbasi, HL Gorgani, H Farahini… - Cancer cell …, 2020 - Springer
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of
osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 …

Targeting Wnt/β-catenin signaling by microRNAs as a therapeutic approach in chemoresistant osteosarcoma

F Hosseini, F Alemi, F Malakoti, A Mahmoodpoor… - Biochemical …, 2021 - Elsevier
Osteosarcoma (OS) is an adolescent and young adult malignancy that mostly occurs in long
bones. The treatment of OS is still a big challenge for clinicians due to increasing …

Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma

Y Hu, Q Yang, L Wang, S Wang, F Sun, D Xu… - Bioscience …, 2018 - portlandpress.com
Aberrant expressions of long non-coding RNAs (lncRNAs) are the culprits of carcinogenesis
via regulating the tumor suppressor or oncogene. LncRNA nuclear enriched abundant …

MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660

H Shan, L Zhu, C Yao, Z Zhang, Y Liu, Q Jiang… - … Therapy-Nucleic Acids, 2021 - cell.com
Osteosarcoma (OS) is the most common primary bone malignancy in the adolescent
population. MAFG (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) …

Circular RNAs in osteosarcoma: An update of recent studies

L Zeng, L Liu, WJ Ni, F Xie… - … Journal of Oncology, 2023 - spandidos-publications.com
Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis
of long bones. As it is associated with a high invasive and metastatic ability, resistance to …