Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Infectious diseases are among the strongest selective pressures driving human evolution,.
This includes the single greatest mortality event in recorded history, the first outbreak of the …

We present WhichTF, a computational method to identify functionally important transcription
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …

Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is
clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and …

The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …

The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

Splicing quantitative trait loci (sQTLs) are one of the major causal mechanisms in genome-
wide association study (GWAS) loci, but their role in disease pathogenesis is poorly …

Systemic lupus erythematosus is a heritable autoimmune disease that predominantly affects
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …