Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF …

YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - Mutation Research …, 2001 - Elsevier
A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Omega-3 fatty acids as cancer chemopreventive agents

DP Rose, JM Connolly - Pharmacology & therapeutics, 1999 - Elsevier
There is both epidemiologic and experimental evidence that the long-chain omega-3 fatty
acids (FAs), which occur at high levels in some fish oils, exert protective effects against some …

Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation

D Salvemini, ZQ Wang, PS Wyatt… - British journal of …, 1996 - Wiley Online Library
1 The role of nitric oxide (NO) derived from constitutive and inducible nitric oxide synthase
(cNOS and iNOS) and its relationship to oxygen‐derived free radicals and prostaglandins …

5-Arylidene-2-imino-4-thiazolidinones: design and synthesis of novel anti-inflammatory agents

R Ottana, R Maccari, ML Barreca, G Bruno… - Bioorganic & medicinal …, 2005 - Elsevier
The synthesis and pharmacological activity of 5-arylidene-2-imino-4-thiazolidinones (3a–8a)
are described. All derivatives exhibited significant activity levels in models of acute …

Regulatory role of nitric oxide in cutaneous inflammation

MQ Man, JS Wakefield, TM Mauro, PM Elias - Inflammation, 2022 - Springer
Nitric oxide (NO), a signaling molecule, regulates biological functions in multiple
organs/tissues, including the epidermis, where it impacts permeability barrier homeostasis …

Macrophages and post-burn immune dysfunction

MG Schwacha - Burns, 2003 - Elsevier
The activation of a pro-inflammatory cascade after burn injury appears to be important in the
development of subsequent immune dysfunction, susceptibility to sepsis and multiple organ …

Bioassay‐guided evaluation of antioxidant and antinociceptive activities of carvacrol

AG Guimarães, GF Oliveira, MS Melo… - Basic & clinical …, 2010 - Wiley Online Library
We examined the antioxidant properties in vitro and the antinociceptive effect of carvacrol
(CARV) in several models of pain in mice. CARV presented a strong antioxidant potential …

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

LM Landino, BC Crews, MD Timmons… - Proceedings of the …, 1996 - National Acad Sciences
Peroxynitrite activates the cyclooxygenase activities of constitutive and inducible
prostaglandin endoperoxide synthases by serving as a substrate for the enzymes' …

Anti‐inflammatory and analgesic effects of paeonol in carrageenan‐evoked thermal hyperalgesia

TC Chou - British journal of pharmacology, 2003 - Wiley Online Library
Paeonol was tested for its anti‐inflammatory and analgesic effects in a rat model of
carrageenan‐evoked thermal hyperalgesia. The possible mechanisms involved in these …

Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation

I Posadas, MC Terencio, I Guillén, ML Ferrándiz… - Naunyn-Schmiedeberg's …, 2000 - Springer
Many in vitro studies have used cell cultures to focus on the relationships between cyclo-
oxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) isoforms. We have …