New perspectives of physiological and pathological functions of nucleolin (NCL)

W Jia, Z Yao, J Zhao, Q Guan, L Gao - Life sciences, 2017 - Elsevier
Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

Structure and functions of nucleolin

H Ginisty, H Sicard, B Roger… - Journal of cell …, 1999 - journals.biologists.com
Nucleolin is an abundant protein of the nucleolus. Nucleolar proteins structurally related to
nucleolin are found in organisms ranging from yeast to plants and mammals. The …

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

O Delattre, J Zucman, B Plougastel, C Desmaze… - Nature, 1992 - nature.com
EWING'S sarcoma and related subtypes of primitive neuroectodermal tumours share a
recurrent and specific t (ll; 22)(q24; q12) chromosome translocation1–8, the breakpoints of …

Causes of genome instability: the effect of low dose chemical exposures in modern society

SAS Langie, G Koppen, D Desaulniers… - …, 2015 - academic.oup.com
Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of …

CM Smith, JA Steitz - Molecular and cellular biology, 1998 - Am Soc Microbiol
We have identified gas5 (growth arrest-specific transcript 5) as a non-protein-coding multiple
small nucleolar RNA (snoRNA) host gene similar to UHG (U22 host gene). Encoded within …

Molecular dissection of nucleolin's role in growth and cell proliferation: new insights

M Srivastava, HB Pollard - The FASEB Journal, 1999 - Wiley Online Library
Cells require optimum protein synthetic activity in order to support cell proliferation, maintain
homeostatic and metabolic integrity, and repair damage. Since growth depends on protein …

Protein ligands to HuR modulate its interaction with target mRNAs in vivo

CM Brennan, IE Gallouzi, JA Steitz - The Journal of cell biology, 2000 - rupress.org
AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene,
cytokine, and lymphokine messages target them for rapid degradation. HuR, a ubiquitously …

High affinity interactions of nucleolin with GG-paired rDNA

LA Hanakahi, H Sun, N Maizels - Journal of Biological Chemistry, 1999 - ASBMB
Nucleolin is a very abundant eukaryotic protein that localizes to the nucleolus, where the
rDNA undergoes transcription, replication, and recombination and where rRNA processing …

The cell-surface-expressed nucleolin is associated with the actin cytoskeleton

AG Hovanessian, F Puvion-Dutilleul, S Nisole… - Experimental cell …, 2000 - Elsevier
Nucleolin is a RNA-and protein-binding multifunctional protein. Mainly characterized as a
nucleolar protein, nucleolin is continuously expressed on the surface of different types of …

Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase (s) modifying arginine …

J Najbauer, BA Johnson, AL Young… - Journal of Biological …, 1993 - Elsevier
Several proteins that interact with RNA, eg the heterogenous ribonucleoprotein particle A
and B proteins, fibrillarin and nucleolin, contain the modified amino acid NG, NG …