Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic
metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental …

Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and
persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic …

Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …

Childhood trauma (CT) is well established as a potent risk factor for the development of
mental disorders. However, the potential of adverse early experiences to exert chronic and …

Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors for all-cause mortality,
cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS …

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia
which is caused by insufficient insulin secretion or insulin resistance. Interaction of genetic …

Purpose: Previous studies found that piRNAs could participate in disease progression by
regulating DNA methylation, but there are few reports on their roles in heart failure (HF) …

Aging as an inevitable phenomenon is associated with pervasive changes in physiological
functions. There is a relationship between aging and the increase of several chronic …

Metabolic syndrome is a complex disease that results from the interplay of genetic and
environmental factors, which increase the comorbidity risk of obesity, hyperglycemia …