The family of NRAMP metal ion transporters functions in diverse organisms from bacteria to
human. NRAMP1 functions in metal transport across the phagosomal membrane of …

The subcellular localization of plasma membrane proteins, such as receptors and
transporters, must be finely tuned so that they can be readily downregulated in response to …

The ubiquitylation of membrane proteins destined for the vacuole/lysosome is essential for
their recognition by the endosomal sorting machinery and their internalization into vesicles …

The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB)
damage. In order to identify conserved genes that mediate DOX resistance, we screened the …

We searched for F-box proteins that might be related to the mechanism that protects
Saccharomyces cerevisiae against the toxic effects of methylmercury. We found that …

Understanding how novel antifungal compounds work in target cells is useful not only in
facilitating the discovery of new drugs but also new tools that can be used for further …

To elucidate the mechanism of acquired resistance to Adriamycin, we searched for genes
that, when overexpressed, render Saccharomyces cerevisiae resistant to Adriamycin. We …

Doxorubicin is one of the most potent anticancer drugs used in the treatment of various
cancer types. The efficacy of doxorubicin is influenced by the drug resistance mechanisms …

We found that overexpression of Bop3, a protein of unknown function, confers resistance to
methylmercury in Saccharomyces cerevisiae. Bmh2, Fkh1, and Rts1 are proteins that have …

Overexpression of the ubiquitin-conjugating enzyme Cdc34 conferred strong cadmium
resistance on budding yeast. Proteasome activity, which is involved in the degradation of …