Free radicals contain one or more unpaired electrons in their valence shell, thus making
them unstable, short-lived, and highly reactive species. Excessive generation of these free …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Melatonin has been shown to protect against oxidative stress in various, highly divergent
experimental systems. There are many reasons for its remarkable protective potential …

This brief review considers some of the cardiac diseases and conditions where free radicals
and related reactants are believed to be causative. The report also describes the beneficial …

Melatonin, acting through melatonin receptors, is involved in numerous physiological
processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Aims We have shown previously that non-toxic inhibition of the ubiquitin–proteasome
system upregulates antioxidative defence mechanisms and protects endothelial cells from …

This review briefly summarizes the actions of melatonin in reducing molecular damage
caused by free radicals and associated oxygen-and nitrogenbased reactants. All the …

Purpose Doxorubicin, as an effective chemotherapeutic drug, is commonly used for
combating various solid and hematological tumors. However, doxorubicin-induced …

Melatonin, one of the evolutionarily most ancient, highly conserved and most pleiotropic
hormones still operative in man, couples complex tissue functions to defined changes in the …