Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis

KJ Kwon-Chung, JA Fraser… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Fungi that infect humans

JR Köhler, B Hube, R Puccia, A Casadevall… - Microbiology …, 2017 - Am Soc Microbiol
Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …

Metals in fungal virulence

F Gerwien, V Skrahina, L Kasper… - FEMS microbiology …, 2018 - academic.oup.com
Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Mechanisms for copper acquisition, distribution and regulation

BE Kim, T Nevitt, DJ Thiele - Nature chemical biology, 2008 - nature.com
Copper (Cu) is a redox-active metal ion essential for most aerobic organisms. Cu serves as
a catalytic and structural cofactor for enzymes that function in energy generation, iron …

Induction and transcriptional regulation of laccases in fungi

A Piscitelli, P Giardina, V Lettera, C Pezzella… - Current …, 2011 - ingentaconnect.com
Fungal laccases are phenol oxidases widely studied for their use in several industrial
applications, including pulp bleaching in paper industry, dye decolourisation, detoxification …

The Yin and Yang of copper during infection

AN Besold, EM Culbertson, VC Culotta - JBIC Journal of Biological …, 2016 - Springer
Copper is an essential micronutrient for both pathogens and the animal hosts they infect.
However, copper can also be toxic in cells due to its redox properties and ability to disrupt …

Copper in microbial pathogenesis: meddling with the metal

MI Samanovic, C Ding, DJ Thiele, KH Darwin - Cell host & microbe, 2012 - cell.com
Transition metals such as iron, zinc, copper, and manganese are essential for the growth
and development of organisms ranging from bacteria to mammals. Numerous studies have …

[HTML][HTML] Charting the travels of copper in eukaryotes from yeast to mammals

T Nevitt, H Öhrvik, DJ Thiele - … et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
Throughout evolution, all organisms have harnessed the redox properties of copper (Cu)
and iron (Fe) as a cofactor or structural determinant of proteins that perform critical functions …

Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence

C Ding, RA Festa, YL Chen, A Espart, Ò Palacios… - Cell host & …, 2013 - cell.com
Copper (Cu) is an essential metal that is toxic at high concentrations. Thus, pathogens often
rely on host Cu for growth, but host cells can hyperaccumulate Cu to exert antimicrobial …

The role of copper homeostasis at the host-pathogen axis: from bacteria to fungi

C Li, Y Li, C Ding - International journal of molecular sciences, 2019 - mdpi.com
Copper is an essential trace element participating in many vital biological processes,
however it becomes a toxic agent when in excess. Thus, precise and tight regulation of …