Recent advances in micro-and nano-scale carrier systems for controlled delivery of vaccines

EY Wang, M Sarmadi, B Ying, A Jaklenec, R Langer - Biomaterials, 2023 - Elsevier
Vaccines provide substantial safety against infectious diseases, saving millions of lives each
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …

[HTML][HTML] Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management

AI d'Aquino, CL Maikawa, LT Nguyen, K Lu, IA Hall… - Cell Reports …, 2023 - cell.com
Summary Glucagon-like peptide-1 (GLP-1) is an incretin hormone and neurotransmitter
secreted from intestinal L cells in response to nutrients to stimulate insulin and block …

Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS‐CoV‐2 Subunit Vaccine

BS Ou, OM Saouaf, J Yan, TUJ Bruun… - Advanced …, 2023 - Wiley Online Library
Most vaccines require several immunizations to induce robust immunity, and indeed, most
SARS‐CoV‐2 vaccines require an initial two‐shot regimen followed by several boosters to …

Injectable controlled‐release systems for the prevention and treatment of infectious diseases

AA Kunkel, KJ McHugh - Journal of Biomedical Materials …, 2023 - Wiley Online Library
Pharmaceutical drugs, including vaccines, pre‐and post‐exposure prophylactics, and
chronic drug therapies, are crucial tools in the prevention and treatment of infectious …

[HTML][HTML] Recent advances in the exploration and discovery of SARS-CoV-2 inhibitory peptides from edible animal proteins

X Kong, W Wang, Y Zhong, N Wang, K Bai, Y Wu… - Frontiers in …, 2024 - frontiersin.org
The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes the
coronavirus disease 2019 (COVID-19), is spreading worldwide. Although the COVID-19 …

A regimen compression strategy for commercial vaccines leveraging an injectable hydrogel depot technology for sustained vaccine exposure

J Yan, BS Ou, OM Saouaf, EL Meany… - Advanced …, 2024 - Wiley Online Library
Equitable global access to vaccines requires overcoming challenges associated with
complex immunization schedules and their associated economic burdens that hinder …

Hydrogel-based drug delivery systems-a review

Kamini, D Puri - Polymer-Plastics Technology and Materials, 2024 - Taylor & Francis
Hydrogels are unique polymer materials that possess hydrophilic chains, allowing them to
effectively retain a considerable amount of water within their interstitial structures. The first …

[PDF][PDF] Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus.

NH Thang, N Van Phuc, TTT Nhi… - Express Polymer …, 2024 - researchgate.net
Polymer-based hydrogels are hydrophilic polymer networks with a remarkable capacity to
absorb substantial amounts of water and biological fluids, rendering them highly attractive …

Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route

H Wang, M Song, J Xu, Z Liu, M Peng, H Qin… - European Journal of …, 2024 - Springer
Because of their high specificity, high affinity, and targeting, antibody drugs have been
widely used in the treatment of many diseases and have become the most favored new …

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

EL Meany, JH Klich, CK Jons, T Mao, N Chaudhary… - bioRxiv, 2024 - biorxiv.org
Messenger RNA (mRNA) delivered in lipid nanoparticles (LNPs) rose to the forefront of
vaccine candidates during the COVID-19 pandemic due in part to scalability, adaptability …