[HTML][HTML] COVID-19 and COPD: a narrative review of the basic science and clinical outcomes
The 2019 coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory
syndrome-coronavirus-2 (SARS-CoV-2). Clinical outcomes, including mortality, are worse in …
syndrome-coronavirus-2 (SARS-CoV-2). Clinical outcomes, including mortality, are worse in …
How inhaled corticosteroids target inflammation in COPD
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …
Prospects for COPD treatment
MG Matera, M Cazzola, C Page - Current Opinion in Pharmacology, 2021 - Elsevier
The management of chronic obstructive pulmonary disease (COPD) is fundamentally still
heavily dependent on the use of bronchodilators and corticosteroids. Therefore, there is a …
heavily dependent on the use of bronchodilators and corticosteroids. Therefore, there is a …
Novel anti-inflammatory approaches to COPD
M Cazzola, NA Hanania, CP Page… - International journal of …, 2023 - Taylor & Francis
Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
Role of p38 mitogen-activated protein kinase in asthma and COPD: pathogenic aspects and potential targeted therapies
Among the various members of the mitogen-activated protein kinase (MAPK) family, p38
MAPK subgroup is the most involved in airway and lung inflammation underlying asthma …
MAPK subgroup is the most involved in airway and lung inflammation underlying asthma …
Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD
Background: Interleukin (IL)-6 trans-signalling (IL-6TS) is emerging as a pathogenic
mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways …
mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways …
Increased mast cell activation in eosinophilic chronic obstructive pulmonary disease
A Higham, J Dungwa, TH Pham… - Clinical & …, 2022 - Wiley Online Library
Objectives A subset of chronic obstructive pulmonary disease (COPD) patients have
increased numbers of airway eosinophils associated with elevated markers of T2 …
increased numbers of airway eosinophils associated with elevated markers of T2 …
Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives
C Pelaia, A Vatrella, A Sciacqua… - Expert Review of …, 2020 - Taylor & Francis
Introduction: The p38 serine-threonine kinases are members of the large family of mitogen-
activated protein kinases (MAPK). In particular, p38 MAPK subgroup includes four isoforms …
activated protein kinases (MAPK). In particular, p38 MAPK subgroup includes four isoforms …
P38 MAPK and glucocorticoid receptor crosstalk in bronchial epithelial cells
S Lea, J Li, J Plumb, K Gaffey, S Mason… - Journal of Molecular …, 2020 - Springer
Abstract p38 MAPK inhibition may have additive and synergistic anti-inflammatory effects
when used with corticosteroids. We investigated crosstalk between p38 MAPK inhibitors and …
when used with corticosteroids. We investigated crosstalk between p38 MAPK inhibitors and …