Nitric oxide (NO), an endogenous, free radical, highly unstable, diatomic gaseous molecule,
plays crucial roles in several physiological and pathological processes. It has attracted …

L‐citrulline (referred to hereafter as citrulline), a non‐essential amino acid and an
intermediate in the urea cycle, is widely recognized for its role in managing genetic urea …

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing
deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in …

X-ray crystallography and structure-based drug discovery have played a major role in the
discovery of antisickling agents that target hemoglobin (Hb) for the treatment of sickle cell …

Abstract The Department of Medicinal Chemistry, together with the Institute for Structural
Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has …

This thesis work focuses on the characterization of red blood cells from sickle cell disease
patients, in particular on new factors that could impact the rheology and the senescence of …