Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19
S Zheng, T Xue, B Wang, H Guo, Q Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of
biological systems, which has become a popular tool in traditional Chinese medicine (TCM) …
biological systems, which has become a popular tool in traditional Chinese medicine (TCM) …
From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or Combating Neospora caninum Infection in Different Susceptible Hosts
RM Fereig, Y Nishikawa - Pathogens, 2020 - mdpi.com
Neospora caninum is an intracellular protozoan parasite affecting numerous animal species.
It induces significant economic losses because of abortion and neonatal abnormalities in …
It induces significant economic losses because of abortion and neonatal abnormalities in …
Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking
X Ruan, P Du, K Zhao, J Huang, H Xia, D Dai… - Chinese Medicine, 2020 - Springer
Background At present, coronavirus disease 2019 (COVID-19), caused by infection with
severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with …
severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with …
Toxoplasma gondii Dense Granule Proteins 7, 14, and 15 Are Involved in Modification and Control of the Immune Response Mediated via NF-κB Pathway
F Ihara, RM Fereig, Y Himori, K Kameyama… - Frontiers in …, 2020 - frontiersin.org
Toxoplasma gondii infects almost all warm-blooded animals, including humans, leading to
both cellular and humoral immune responses in the host. The virulence of T. gondii is strain …
both cellular and humoral immune responses in the host. The virulence of T. gondii is strain …
Efficient gene knockout and knockdown systems in Neospora caninum enable rapid discovery and functional assessment of novel proteins
The development of molecular genetics has greatly enhanced the study of the biology and
pathology associated with parasites of the phylum Apicomplexa. While the molecular tools …
pathology associated with parasites of the phylum Apicomplexa. While the molecular tools …
NcGRA7 and NcROP40 Play a Role in the Virulence of Neospora caninum in a Pregnant Mouse Model
L Rico-San Román, R Amieva, J Regidor-Cerrillo… - Pathogens, 2022 - mdpi.com
The intraspecific variability among Neospora caninum isolates in their in vitro behaviour and
in vivo virulence has been widely studied. In particular, transcriptomic and proteomic …
in vivo virulence has been widely studied. In particular, transcriptomic and proteomic …
Neospora GRA6 possesses immune-stimulating activity and confers efficient protection against Neospora caninum infection in mice
RM Fereig, N Shimoda, HH Abdelbaky, Y Kuroda… - Veterinary …, 2019 - Elsevier
Vaccination has the potential to be the most cost-effective control measure for reducing the
economic burden of neosporosis in cattle. In this study, the immune-stimulatory effect of …
economic burden of neosporosis in cattle. In this study, the immune-stimulatory effect of …
Neospora caninum infection induces an isolate virulence-dependent pro-inflammatory gene expression profile in bovine monocyte-derived macrophages
M García-Sánchez, L Jiménez-Pelayo, P Horcajo… - Parasites & …, 2020 - Springer
Background Neospora caninum is an obligate intracellular parasite, and its ability to survive
inside host immune cells may be a key mechanism for the establishment of infection in …
inside host immune cells may be a key mechanism for the establishment of infection in …
A preliminary study on placental damage associated to experimental neosporosis in BALB/c mice
Z Tang, H Li, S Xie, S Zhao, S Zhang, H Wang, N Li… - Parasitology …, 2023 - Springer
Neospora caninum is a protozoan parasite which can infect a range of animals, including
dogs, cattle, and sheep. Bovine neosporosis, which mainly causes abortion in cattle, results …
dogs, cattle, and sheep. Bovine neosporosis, which mainly causes abortion in cattle, results …
Comparative Evaluation of Four Potent Neospora caninum Diagnostic Antigens Using Immunochromatographic Assay for Detection of Specific Antibody in Cattle
RM Fereig, HH Abdelbaky, Y Nishikawa - Microorganisms, 2021 - mdpi.com
Neospora caninum is an intracellular protozoan parasite responsible for numerous abortion
outbreaks and neonatal abnormalities in cattle. Rapid and accurate diagnosis is critical for …
outbreaks and neonatal abnormalities in cattle. Rapid and accurate diagnosis is critical for …