Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19

S Zheng, T Xue, B Wang, H Guo, Q Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of
biological systems, which has become a popular tool in traditional Chinese medicine (TCM) …

From Signaling Pathways to Distinct Immune Responses: Key Factors for Establishing or Combating Neospora caninum Infection in Different Susceptible Hosts

RM Fereig, Y Nishikawa - Pathogens, 2020 - mdpi.com
Neospora caninum is an intracellular protozoan parasite affecting numerous animal species.
It induces significant economic losses because of abortion and neonatal abnormalities in …

Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking

X Ruan, P Du, K Zhao, J Huang, H Xia, D Dai… - Chinese Medicine, 2020 - Springer
Background At present, coronavirus disease 2019 (COVID-19), caused by infection with
severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with …

Toxoplasma gondii Dense Granule Proteins 7, 14, and 15 Are Involved in Modification and Control of the Immune Response Mediated via NF-κB Pathway

F Ihara, RM Fereig, Y Himori, K Kameyama… - Frontiers in …, 2020 - frontiersin.org
Toxoplasma gondii infects almost all warm-blooded animals, including humans, leading to
both cellular and humoral immune responses in the host. The virulence of T. gondii is strain …

Efficient gene knockout and knockdown systems in Neospora caninum enable rapid discovery and functional assessment of novel proteins

TWP Mineo, JH Chern, AC Thind, CM Mota… - Msphere, 2022 - Am Soc Microbiol
The development of molecular genetics has greatly enhanced the study of the biology and
pathology associated with parasites of the phylum Apicomplexa. While the molecular tools …

NcGRA7 and NcROP40 Play a Role in the Virulence of Neospora caninum in a Pregnant Mouse Model

L Rico-San Román, R Amieva, J Regidor-Cerrillo… - Pathogens, 2022 - mdpi.com
The intraspecific variability among Neospora caninum isolates in their in vitro behaviour and
in vivo virulence has been widely studied. In particular, transcriptomic and proteomic …

Neospora GRA6 possesses immune-stimulating activity and confers efficient protection against Neospora caninum infection in mice

RM Fereig, N Shimoda, HH Abdelbaky, Y Kuroda… - Veterinary …, 2019 - Elsevier
Vaccination has the potential to be the most cost-effective control measure for reducing the
economic burden of neosporosis in cattle. In this study, the immune-stimulatory effect of …

Neospora caninum infection induces an isolate virulence-dependent pro-inflammatory gene expression profile in bovine monocyte-derived macrophages

M García-Sánchez, L Jiménez-Pelayo, P Horcajo… - Parasites & …, 2020 - Springer
Background Neospora caninum is an obligate intracellular parasite, and its ability to survive
inside host immune cells may be a key mechanism for the establishment of infection in …

A preliminary study on placental damage associated to experimental neosporosis in BALB/c mice

Z Tang, H Li, S Xie, S Zhao, S Zhang, H Wang, N Li… - Parasitology …, 2023 - Springer
Neospora caninum is a protozoan parasite which can infect a range of animals, including
dogs, cattle, and sheep. Bovine neosporosis, which mainly causes abortion in cattle, results …

Comparative Evaluation of Four Potent Neospora caninum Diagnostic Antigens Using Immunochromatographic Assay for Detection of Specific Antibody in Cattle

RM Fereig, HH Abdelbaky, Y Nishikawa - Microorganisms, 2021 - mdpi.com
Neospora caninum is an intracellular protozoan parasite responsible for numerous abortion
outbreaks and neonatal abnormalities in cattle. Rapid and accurate diagnosis is critical for …