Roles and therapeutic implications of m6A modification in cancer immunotherapy
J Pan, T Huang, Z Deng, C Zou - Frontiers in Immunology, 2023 - frontiersin.org
Recent studies have demonstrated that N6-methyladenosine (m6A), the most abundant,
dynamic, and reversible epigenetic RNA modification in eukaryotes, is regulated by a series …
dynamic, and reversible epigenetic RNA modification in eukaryotes, is regulated by a series …
RNA modification m6Am: the role in cardiac biology
Epitranscriptomic modifications have recently emerged into the spotlight of researchers due
to their vast regulatory effects on gene expression and thereby cellular physiology and …
to their vast regulatory effects on gene expression and thereby cellular physiology and …
The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma
K Li, J Chen, C Zhang, M Cheng… - The Journal of …, 2023 - Am Soc Clin Investig
PCIF1 can mediate the methylation of N 6, 2′-O-dimethyladenosine (m6Am) in mRNA. Yet,
the detailed interplay between PCIF1 and the potential cofactors and its pathological …
the detailed interplay between PCIF1 and the potential cofactors and its pathological …
[HTML][HTML] Downregulation of FTO in the hippocampus is associated with mental disorders induced by fear stress during pregnancy
Mental disorders (MD), such as anxiety, depression, and cognitive impairment, are very
common during pregnancy and predispose to adverse pregnancy outcomes; however, the …
common during pregnancy and predispose to adverse pregnancy outcomes; however, the …
Untacking small RNA profiling and RNA fragment footprinting: Approaches and challenges in library construction
Small RNAs (sRNAs) with sizes ranging from 15 to 50 nucleotides (nt) are critical regulators
of gene expression control. Prior studies have shown that sRNAs are involved in a broad …
of gene expression control. Prior studies have shown that sRNAs are involved in a broad …
An Overview of Current Detection Methods for RNA Methylation
B Sağlam, B Akgül - International Journal of Molecular Sciences, 2024 - mdpi.com
Epitranscriptomic mechanisms, which constitute an important layer in post-transcriptional
gene regulation, are involved in numerous cellular processes under health and disease …
gene regulation, are involved in numerous cellular processes under health and disease …
RNA modifications in physiology and pathology: Progressing towards application in clinical settings
X Jiang, L Zhan, X Tang - Cellular Signalling, 2024 - Elsevier
The potential to modify individual nucleotides through chemical means in order to impact the
electrostatic charge, hydrophobic properties, and base pairing of RNA molecules is …
electrostatic charge, hydrophobic properties, and base pairing of RNA molecules is …
Cap-specific terminal N6-methyladeonsine methylation of RNA mediated by PCIF1 and possible therapeutic implications
H Zeng, Y Wu, X Long - Genes & Diseases, 2023 - Elsevier
Posttranscriptional RNA modification is an important mode of epigenetic regulation in
various biological and pathological contexts. N6, 2′-O-dimethyladenosine (m6Am) is one …
various biological and pathological contexts. N6, 2′-O-dimethyladenosine (m6Am) is one …
[HTML][HTML] Sequencing methods and functional decoding of mRNA modifications
K Li, J Peng, C Yi - Fundamental Research, 2023 - Elsevier
More than 160 types of post-transcriptional RNA modifications have been reported; there is
substantial variation in modification type, abundance, site, and function across species …
substantial variation in modification type, abundance, site, and function across species …
An Overview of Current Detection Methods for RNA Methylation
B Saglam, B Akgül - Int. J. Mol. Sci, 2024 - europepmc.org
Epitranscriptomic mechanisms, which constitute an important layer in post-transcriptional
gene regulation, are involved in numerous cellular processes under health and disease …
gene regulation, are involved in numerous cellular processes under health and disease …