The evolutionary origins of pesticide resistance
Durable crop protection is an essential component of current and future food security.
However, the effectiveness of pesticides is threatened by the evolution of resistant …
However, the effectiveness of pesticides is threatened by the evolution of resistant …
Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution
Background and objectives To understand how organisms evolve, it is fundamental to study
how mutations emerge and establish. Here, we estimated the rate of mutation accumulation …
how mutations emerge and establish. Here, we estimated the rate of mutation accumulation …
[HTML][HTML] Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins
The degree to which evolution is predictable is a fundamental question in biology. Previous
attempts to predict the evolution of protein sequences have been limited to specific proteins …
attempts to predict the evolution of protein sequences have been limited to specific proteins …
Epistatic models predict mutable sites in SARS-CoV-2 proteins and epitopes
J Rodriguez-Rivas, G Croce… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is a major concern given their potential impact on the transmissibility and …
CoV-2) is a major concern given their potential impact on the transmissibility and …
Epistasis and adaptation on fitness landscapes
C Bank - Annual Review of Ecology, Evolution, and Systematics, 2022 - annualreviews.org
Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …
Towards multidrug adaptive therapy
A new ecologically inspired paradigm in cancer treatment known as “adaptive therapy”
capitalizes on competitive interactions between drug-sensitive and drug-resistant subclones …
capitalizes on competitive interactions between drug-sensitive and drug-resistant subclones …
Quantification of subclonal selection in cancer from bulk sequencing data
Subclonal architectures are prevalent across cancer types. However, the temporal
evolutionary dynamics that produce tumor subclones remain unknown. Here we measure …
evolutionary dynamics that produce tumor subclones remain unknown. Here we measure …
Evolution in the light of fitness landscape theory
By formalizing the relationship between genotype or phenotype and fitness, fitness
landscapes harbor information on molecular and evolutionary constraints. The shape of the …
landscapes harbor information on molecular and evolutionary constraints. The shape of the …
Natural selection and the predictability of evolution in Timema stick insects
Predicting evolution remains difficult. We studied the evolution of cryptic body coloration and
pattern in a stick insect using 25 years of field data, experiments, and genomics. We found …
pattern in a stick insect using 25 years of field data, experiments, and genomics. We found …