The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering

P Abdollahiyan, F Oroojalian… - Journal of controlled …, 2021 - Elsevier
As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to
address unmet clinical needs for the repair and replacement of human damaged organs …

[HTML][HTML] MG53, a tissue repair protein with broad applications in regenerative medicine

Z Li, L Wang, H Yue, BA Whitson, E Haggard, X Xu… - Cells, 2021 - mdpi.com
Under natural conditions, injured cells can be repaired rapidly through inherent biological
processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy …

[HTML][HTML] MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing

X Sun, W Song, L Teng, Y Huang, J Liu, Y Peng, X Lu… - Bioactive Materials, 2023 - Elsevier
The damage of corneal epithelium may lead to the formation of irreversible corneal opacities
and even blindness. The migration rate of corneal epithelial cells directly affects corneal …

[HTML][HTML] MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

M Sermersheim, AD Kenney, PH Lin… - Nature …, 2020 - nature.com
TRIM family proteins play integral roles in the innate immune response to virus infection.
MG53 (TRIM72) is essential for cell membrane repair and is believed to be a muscle-specific …

Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H2O2-Activated Protein Kinase C-δ Signaling

D Shan, S Guo, HK Wu, F Lv, L Jin, M Zhang, P Xie… - Circulation, 2020 - Am Heart Assoc
Background: Ischemic heart disease is the leading cause of morbidity and mortality
worldwide. Ischemic preconditioning (IPC) is the most powerful intrinsic protection against …

TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy‐Mediated NLRP3 Inflammasome Inactivation

M Wu, H Li, J He, J Liang, Y Liu… - Oxidative medicine and …, 2023 - Wiley Online Library
Chronic muscle inflammation exacerbates the pathogenesis of Duchenne muscular
dystrophy (DMD), which is characterized by progressive muscle degeneration and …

MG53 Does Not Manifest the Development of Diabetes in db/db Mice

Q Wang, Z Bian, Q Jiang, X Wang, X Zhou, KH Park… - Diabetes, 2020 - Am Diabetes Assoc
MG53 is a member of the TRIM protein family that is predominantly expressed in striated
muscles and participates in cell membrane repair. Controversy exists regarding MG53's role …

[HTML][HTML] Ocular Wnt/β-catenin pathway inhibitor XAV939-loaded liposomes for treating alkali-burned corneal wound and neovascularization

Y Zhong, K Wang, Y Zhang, Q Yin, S Li… - … in Bioengineering and …, 2021 - frontiersin.org
Corneal wound involves a series of complex and coordinated physiological processes,
leading to persistent epithelial defects and opacification. An obstacle in the treatment of …

Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration

BA Whitson, T Tan, N Gong, H Zhu, J Ma - Current opinion in pharmacology, 2021 - Elsevier
Through stress and injury to tissues, the cell membrane is damaged and can lead to cell
death and a cascade of inflammatory events. Soluble factors that mitigate and repair …

MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis

C Liu, Y Hu, Y Han, Y Wang, Y Zhang… - Acta pharmacologica …, 2020 - nature.com
Abstract Mitsugumin 53 (MG53) is a tripartite motif family protein that has been reported to
attenuate injury via membrane repair in different organs. Contrast-induced acute kidney …