Forecasting alterations in protein stability caused by variations holds immense importance.
Improving the thermal stability of proteins is important for biomedical and industrial …

Helices are important secondary structural motifs within proteins and are pivotal in
numerous physiological processes. While amino acids (AA) such as alanine and leucine are …

The protein-peptide interaction plays a pivotal role in fields such as drug development, yet
remains underexplored experimentally and challenging to model computationally. Herein …

Complementarity determining region (CDR) is a specific region in antibody molecules that
binds to antigens, where a small portion of residues undergoes particularly pronounced …

Therapeutic antibodies such as monoclonal antibodies (mAbs), bispecific and multispecific
antibodies are pivotal in therapeutic protein development and have transformed disease …

Tumor homing peptides (THPs) play significant role in recognizing and specifically binding
to tumor cells. Traditional experimental methods can accurately identify THPs but often suffer …

The prediction of the impact of amino acid mutations on the change in binding free energy
(\varDelta\varDeltaG), is critically important for both biomedical and industrial applications …

The advent of machine learning (ML) has significantly advanced enzyme engineering,
particularly through zero‐shot (ZS) predictors that forecast the effects of amino acid …