The vast majority of drugs entering human trials fail. This problem (called “attrition”) is widely
recognized as a public health crisis, and has been discussed openly for the last two …

It took decades to arrive at the general consensus dismissing the notion that the immune
system is independent of the central nervous system. In the case of uncontrolled systemic …

Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment,
including learning, memory and attention deficits. Antipsychotic drugs are limited in their …

New 2-oxo-chromene-7-oxymethylene acetohydrazide derivatives 4a–d were designed and
synthesized with a variety of bioactive chemical fragments. The newly synthesized …

Tamarindus indica Linn.(Tamarind, F. Fabaceae) is one of the most widely consumed fruits
in the world. A crude extract and different fractions of T. indica (using n-hexane …

Automated home-cage monitoring systems present a valuable tool for comprehensive
phenotyping of natural behaviors. However, current systems often involve complex training …

A series of novel benzofuran-based compounds 7a-s were designed, synthesized, and
investigated in vitro as acetylcholinesterase inhibitors (AChEIs). Compounds 7c and 7e …

To evaluate permanent effects of hippocampal and prefrontal cortex lesion on spatial tasks,
lesioned and sham-operated female C57BL/6 mice were exposed to a series of conditioning …

Prosocial behaviour, including helping behaviour, benefits others. Recently, helping-like
behaviour has been observed in rats, but whether it is oriented towards rescue, social …

The severe motor impairment in the MS animal model experimental autoimmune
encephalomyelitis (EAE) obstructs the assessment of cognitive functions. We developed an …