Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …

The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

Bone is a dynamic tissue that can always rebuild itself by modeling and remodeling to
maintain functionality. This tissue is responsible for several vital functions in the body, such …

Due to the overexpression or amplification of human epidermal growth factor receptor 2
(HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on …

Deciphering the ways in which somatic mutations and germline susceptibility variants
cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions …

Bone-marrow-derived mesenchymal stem cells (MSCs) are of growing interest for the
treatment of diabetic wound healing. However, they are often associated with poor …

Adipocytes control bone mass, but the mechanism is unclear. To explore the effect of
postnatal adipocyte elimination on bone cells, we mated mice expressing an inducible …

Stem cell identity and plasticity are controlled by master regulatory genes and complex
circuits also involving non-coding RNAs. Circular RNAs (circRNAs) are a class of RNAs …