MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently
deregulated in many human diseases, including cancer and immunological disorders, it is …

Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Polycomb group (PcG) proteins are major determinants of gene silencing and epigenetic
memory in higher eukaryotes. Here, we systematically mapped the human PcG complexome …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

The mixed lineage leukaemia (MLL) family of proteins (including MLL1–MLL4, SET1A and
SET1B) specifically methylate histone 3 Lys4, and have pivotal roles in the transcriptional …

Epigenetic dysregulation has emerged as a recurring mechanism in the etiology of
neurodevelopmental disorders. Two such disorders, CHARGE and Kabuki syndromes …

Although many long non-coding RNAs (lncRNAs) have been discovered, their function and
their association with RNAi factors in the nucleus have remained obscure. Here, we identify …

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper
regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding …

WDR5 (WD40 repeat protein 5) is an essential component of the human trithorax-like family
of SET1 [Su (var) 3–9 enhancer-of-zeste trithorax 1] methyltransferase complexes that carry …